High dose barbiturates in non-traumatic brain swelling.

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High dose barbiturates in non-traumatic brain swelling.

High dose barbiturates were used to treat intracranial hypertension in 15 patients with nontraumatic brain lesions; (3 hypertensive hemorrhage, 4 subarachnoid hemorrhage, 5 infarction, 2 global anoxia-ischemia and 2 encephalitis). All had persistently raised intracranial pressure (ICP) while being treated with aggressive conventional therapy. The addition of barbiturates caused an initial lower...

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High-dose barbiturates for refractory intracranial hypertension in children with severe traumatic brain injury.

OBJECTIVES To evaluate high-dose barbiturates as a second-tier therapy for pediatric refractory intracranial hypertension complicating severe traumatic brain injury. DESIGN This is a retrospective cohort study of children with refractory intracranial hypertension treated with high-dose barbiturates. SETTING A single center level I pediatric trauma from 2001 to 2010. PATIENTS Thirty-six ch...

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Diffusion tensor imaging in an infant with traumatic brain swelling.

We present the case of a 14-month-old male infant who underwent diffusion tensor imaging within 24 hours of traumatic brain injury. Although conventional MR findings that included those of diffusion-weighted imaging were unremarkable, full-tensor diffusion imaging revealed striking abnormalities in regions of brain that subsequently developed overt swelling. This case engenders important hypoth...

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Barbiturates for the treatment of intracranial hypertension after traumatic brain injury

In their article on the use of barbiturates for the treatment of intracranial hypertension after traumatic brain injury, Perez-Barcena and colleagues conclude that thiopental was more effective than pentobarbital in decreasing intracranial pressure. Here we discuss the limitations of this study and review areas of controversy surrounding barbiturate use in neurocritical care.

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ژورنال

عنوان ژورنال: Stroke

سال: 1983

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.14.5.830